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Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-Up Cohort: A pilot study.
CONCLUSIONSDPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN. PMID: 24144652 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 21, 2013 Category: Endocrinology Authors: Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, for The SEARCH For Diabetes In Youth Study Group Tags: Diabetes Care Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

The clinical characteristics and mutation search within monogenic diabetes genes in type 1 diabetes patients with long-term disease and preserved kidney function
CONCLUSIONS: Patients with long-term T1DM and well-preserved kidney function are characterized by good glycemic control, high HDL-cholesterol, low insulin requirements and near normal BMI. Monogenic diabetes mutations are not frequent among them.PMID:34825797 | DOI:10.20452/pamw.16143
Source: Molecular Medicine - November 26, 2021 Category: Molecular Biology Authors: Jerzy Hohendorff Magdalena Kwiatkowska Dorota Pisarczyk-Wiza Agnieszka Ludwig-S łomczyńska Magdalena Milcarek Przemys ław Kapusta Barbara Zapa ła Beata Kie ć-Wilk Iwona Trznadel-Morawska Magdalena Szopa Dorota Zozuli ńska-Ziółkiewicz Maciej T Ma Source Type: research

Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study
CONCLUSIONS The high rates of DPN among youth with diabetes are a cause of concern and suggest a need for early screening and better risk factor management. Interventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications.
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Jaiswal, M.; Divers, J.; Dabelea, D.; Isom, S.; Bell, R. A.; Martin, C. L.; Pettitt, D. J.; Saydah, S.; Pihoker, C.; Standiford, D. A.; Dolan, L. M.; Marcovina, S.; Linder, B.; Liese, A. D.; Pop-Busui, R.; Feldman, E. L. Tags: Complications-Neuropathy Pathophysiology/Complications Source Type: research

Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
In conclusion, the pertinent pre-clinical studies evidenced the calcium phosphate biocompatibility and its effectiveness in delivering SIM to improve the repair of bone defects. So, clinical trials are encouraged to investigate the impact of SIM associated with calcium phosphate bone graft in repairing bone defect in humans. PMID: 32556021 [PubMed - in process]
Source: Braz Dent J - February 29, 2020 Category: Dentistry Authors: Cruz R, Pesce G, Calasans-Maia J, Moraschini V, Calasans-Maia MD, Granjeiro JM Tags: Braz Dent J Source Type: research

Sugar-sweetened beverage intake and cardiovascular risk factor profile in youth with type 1 diabetes: application of measurement error methodology in the SEARCH Nutrition Ancillary Study.
Abstract The SEARCH Nutrition Ancillary Study aims to investigate the role of dietary intake on the development of long-term complications of type 1 diabetes in youth, and capitalise on measurement error (ME) adjustment methodology. Using the National Cancer Institute (NCI) method for episodically consumed foods, we evaluated the relationship between sugar-sweetened beverage (SSB) intake and cardiovascular risk factor profile, with the application of ME adjustment methodology. The calibration sample included 166 youth with two FFQ and three 24 h dietary recall data within 1 month. The full sample included 2286 yo...
Source: The British Journal of Nutrition - July 16, 2015 Category: Nutrition Authors: Liese AD, Crandell JL, Tooze JA, Kipnis V, Bell R, Couch SC, Dabelea D, Crume TL, Mayer-Davis EJ Tags: Br J Nutr Source Type: research

Predictors of Dyslipidemia Over Time in Youth With Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study
CONCLUSIONS A1C and WHtR are modifiable risk factors associated with change in dyslipidemia over time in youth with type 1 diabetes.
Source: Diabetes Care - March 20, 2017 Category: Endocrinology Authors: Shah, A. S.; Maahs, D. M.; Stafford, J. M.; Dolan, L. M.; Lang, W.; Imperatore, G.; Bell, R. A.; Liese, A. D.; Reynolds, K.; Pihoker, C.; Marcovina, S.; DAgostino, R. B.; Dabelea, D. Tags: Cardiovascular and Metabolic Risk Source Type: research

Cardiovascular Risk Factors Are Associated With Increased Arterial Stiffness in Youth With Type 1 Diabetes: The SEARCH CVD study.
CONCLUSIONSPresence, clustering, and worsening of CV risk factors are associated with increased arterial stiffness over time in youth with type 1 diabetes. Whether improvement in CV risk factors early in life will slow the progression of arterial stiffness and reduce the burden of CV disease in this population requires further study. PMID: 24101697 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 7, 2013 Category: Endocrinology Authors: Dabelea D, Talton JW, D'Agostino R, Wadwa RP, Urbina EM, Dolan LM, Daniels SR, Marcovina SM, Hamman RF Tags: Diabetes Care Source Type: research

Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database
ConclusionIn this retrospective cohort of men undergoing RP, postoperative statin use was significantly associated with reduced risk of BCR.Whether the association between postoperative statin use and BCR differs by race requires further study.Given these findings, coupled with other studies suggesting that statins may reduce risk of advanced PC, randomized controlled trials are warranted to formally test the hypothesis that statins slow PC progression.
Source: BJU International - March 3, 2014 Category: Urology & Nephrology Authors: Emma H. Allott, Lauren E. Howard, Matthew R. Cooperberg, Christopher J. Kane, William J. Aronson, Martha K. Terris, Christopher L. Amling, Stephen J. Freedland Tags: Urological Oncology Source Type: research

Longitudinal association between television watching and computer use and risk markers in diabetes in the SEARCH for Diabetes in Youth Study
ConclusionsYouth with T2D who increased their television watching over time vs. those who decreased it had larger increases in HbA1c over 5 yr. Youth with T1D who increased their television watching over time had increases in LDL‐c, TG, and to a lesser extent HbA1c.
Source: Pediatric Diabetes - June 1, 2014 Category: Endocrinology Authors: Chao Li, Bettina Beech, Tessa Crume, Ralph B D'Agostino, Dana Dabelea, Jill L Kaar, Angela D Liese, Elizabeth J Mayer‐Davis, Russell Pate, David J Pettitt, Craig Taplin, Beatriz Rodriguez, Anwar T Merchant Tags: Original Article Source Type: research

Exercise for people with high cardiovascular risk.
CONCLUSIONS: Evidence to date is entirely limited to small studies with regard to sample size, short-term follow-up, and high risk of methodological bias, which makes it difficult to derive any conclusions on the efficacy or safety of aerobic or resistance exercise on groups with increased cardiovascular risk or in individuals with two or more coexisting risk factors. Further randomized clinical trials assessing controlled exercise programmes on total cardiovascular risk in individuals are warranted. PMID: 25120097 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 13, 2014 Category: Journals (General) Authors: Seron P, Lanas F, Pardo Hernandez H, Bonfill Cosp X Tags: Cochrane Database Syst Rev Source Type: research

Search for the Most 'primitive' Membranes and Their Reinforcers: A Review of the Polyprenyl Phosphates Theory.
Abstract Terpenoids have an essential function in present-day cellular membranes, either as membrane reinforcers in Eucarya and Bacteria or as principal membrane constituents in Archaea. We have shown that some terpenoids, such as cholesterol and α, ω-dipolar carotenoids reinforce lipid membranes by measuring the water permeability of unilamellar vesicles. It was possible to arrange the known membrane terpenoids in a 'phylogenetic' sequence, and a retrograde analysis led us to conceive that single-chain polyprenyl phosphates might have been 'primitive' membrane constituents. By using an optical microscopy, we ha...
Source: Origins of Life and Evolution of the Biosphere - October 30, 2014 Category: Molecular Biology Authors: Nakatani Y, Ribeiro N, Streiff S, Gotoh M, Pozzi G, Désaubry L, Milon A Tags: Orig Life Evol Biosph Source Type: research

UK DNA shared in worldwide search for genetic causes of disease
The genomes of thousands of Britons have been used to identify rare genetic varients that raise the risk of illnesses including heart disease and obesityThe DNA of thousands of British people has been read and made available to researchers around the world to boost the search for genetic causes of disease.The genomes of 4,000 healthy people are being shared with international scientists, along with detailed information on the participants’ height, weight, blood pressure, cholesterol levels and 60 other medical measurements. Continue reading...
Source: Guardian Unlimited Science - September 15, 2015 Category: Science Authors: Ian Sample Science editor Tags: Genetics Science Medical research Biology Source Type: news

In Search of an Optimal Target Level of Low Density Lipoprotein Cholesterol for Secondary Prevention Among the Japanese Population.
Authors: Morita H, Ishizaka N PMID: 26830202 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - February 3, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of bedtime melatonin consumption on diabetes control and lipid profile
Abstract Hormonal change in carbohydrate metabolism through the circadian rhythm is well known. An impaired nocturnal insulin secretion and lower level melatonin coexist in diabetics at the end of the night period. Administration of melatonin may improve impaired insulin secretion and control hyperglycemia. In a randomized, double-blind study, 64 type 2 tics were treated for 12 weeks (period 1) with placebo, and then for another 12 weeks (period 2) with 6 mg of melatonin. Fasting blood glucose (FBG), total triglyceride (TG), total cholesterol (CHOL), high-density (HDL), and low-density lipoprotein (LDL) cholest...
Source: International Journal of Diabetes in Developing Countries - May 13, 2016 Category: Endocrinology Source Type: research